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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Glia. 2012 Aug 1;60(11):1660–1670. doi: 10.1002/glia.22384

Fig. 5. Minocycline also reduces the development of neuropathic pain symptoms after mild spinal cord injury, but less efficiently than deletion of Cx43.

Fig. 5

(A) Bar histogram shows the effects of minocycline on mechanical allodynia. Significant attenuation of mechanical allodynia was observed 4–8 weeks after spinal cord injury in mice receiving minocycline compared with vehicle controls exposed to the same injury (**P < 0.05, ANOVA, n = 12) (B) Bar histogram shows the effects of minocycline on the development of heat hyperalgesia. Heat hyperalgesia was significantly reduced in mice receiving minocycline 4–8 weeks after spinal cord injury compared with vehicle controls (**P < 0.05, ANOVA, n = 12, mean ± SEM). (C and D) Graph comparing the analgesic effects of minocycline versus deletion of Cx43/Cx30. Both set of data was normalized to littermate controls exposed to the same injury. Deletion of Cx43/Cx30 leads to a significantly greater reduction of mechanical allodynia and heat thermal hyperalgesia after spinal cord injury (P < 0.01, ANOVA, n = 6).