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Recruitment of cyclin E/Cdk2/Xic1 and SCF to replication origins. Xic1 forms a ternary complex with cyclin E/Cdk2 and binds to ORC/Cdc6 at replication origins (left). Mcm2-7 binding to replication origins (“licensing”) depends on ORC, Cdc6 and Cdt1; SCF is recruited to licensed chromatin containing Mcm2-7 (right). Although it is likely that both assembly reactions can occur at the same origin, this has not been proven.
