Skip to main content
. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Cell Microbiol. 2012 Feb 8;14(4):560–576. doi: 10.1111/j.1462-5822.2011.01742.x

Fig. 8. Proposed model of intracellular transport of LDL-CHOL to Anaplasma inclusions.

Fig. 8

A. phagocytophilum hijacks free cholesterol from NPC1 vesicles on the way to Trans-Golgi network. Blue arrows indicate vesicular and cholesterol traffic pathways in uninfected cells. Red arrows indicate vesicular and cholesterol traffic pathways induced by Anaplasma infection. Yellow dot, non-esterified cholesterol; orange ball (esterified cholesterol) in LDL (low-density lipoprotein) and LD (lipid droplet); LDLR, low-density lipoprotein receptor; EE, early endosome; LE, late endosome; LY, lysosome; ER, endoplasmic reticulum; SREBP, sterol regulatory element-binding protein.