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. Author manuscript; available in PMC: 2013 Mar 21.
Published in final edited form as: Am J Obstet Gynecol. 2010 May;202(5):431.e1–431.34. doi: 10.1016/j.ajog.2010.03.026

Table 10.

IPA networks of maternal genes

Network Molecules* Calculated
Score		 Focus
molecules		 Top Functions of Network
1 AGT, AGTR1, Akt, COL4A2, Collagen(s), Creb, Cyclin A, Cyclin E, ERK, ERK1/2, FAK, FGF1, G-protein beta, GNB3, IGF1, IL6R, Insulin, Laminin, Mapk, Mek, Mlc, OXTR, p70 S6k, PDGF BB, PI3K, Pkc(s), PLC, Ras, Ras homolog, Rsk, Shc, STAT, THPO, TIMP2, Vegf 20 10 Cardiovascular System Development and Function, Tissue Morphology, Cellular Growth and Proliferation
2 Angiotensin II receptor type 1, C8, Calcineurin protein(s), Cyclooxygenase, F3, Fibrinogen, Ifn gamma, Ige, IgG, Ikb, IKK (complex), IL1, IL10, IL18, IL12 (complex), Il12 receptor, IL12B, Interferon alpha, LDL, MHC Class II, Mmp, MMP16, Nfat (family), NFkB (complex), NfkB-RelA, Nos, P38 MAPK, SELE, SERPINE1, Sod, STAT5a/b, Tgf beta, Tlr, TLR2, VEGFC 18 9 Cell-mediated Immune Response, Cellular Movement, Hematological System Development and Function
3 ACAN, acetaldehyde, ADAMTS1, Ap1, Calmodulin, Caspase, COL4A3, COL4A4 (includes EG:1286), FGFR1, FSH, Histone h3, Hsp70, HTR2A, IL17A (includes EG:3605), IL1B, ITGA3, Jnk, LRPAP1, LTF, MIF, MMP3, MMP7, MMP13, platelet activating factor, PTH, RAPGEF1, REN, SNCG, THBS4, Timp, TIMP2, Tnf receptor, Trypsin, xanthine, XDH 16 8 Connective Tissue Disorders, Genetic Disorder, Cellular Movement
4 ACAN, ADAM17, AFP, alcohol, CCL7, COL5A2, CRHR2, CRK, CXCL12, EGFR, FCER2, Fgfr, FGFR1, HMGA2, HSPG2 (includes EG:3339), IL6, IL17A (includes EG:3605), ITGA5, Mmp, MMP3, MMP7, MMP10, MMP13, MMP17, NQO1, platelet activating factor, PLC gamma, PTPN6, SAA2, TBXAS1, testosterone, Timp, TIMP2, TIMP4, TNF 12 6 Cellular Movement, Connective Tissue Disorders, Genetic Disorder
*

Focus molecules are underlined.