Table 4.

SNPs found to be significantly associated with spontaneous preterm labor/delivery in single locus tests of association (p < 0.01)

Population	Gene Code	rs#	Minor Allele	Minor Allele Frequency		OR1	95% CI2		p-value
				Cases	Controls		Lower	Upper
Maternal (Cases n = 223; Controls n = 99)	IL6R	rs8192282	A	0.13	0.08	1.70	1.19	2.41	0.003
	COL4A3	rs1882435	A	0.33	0.26	1.40	1.10	1.79	0.007
	LTF	rs2269435	C	0.38	0.3	1.39	1.10	1.76	0.007
	FGF1	rs34003	G	0.32	0.41	0.69	0.54	0.87	0.002
	GNB3	rs5440	G	0.36	0.43	0.73	0.58	0.92	0.007
	IGF1	rs5742612	C	0.06	0.10	0.56	0.36	0.87	0.009
	TIMP2	rs2277698	A	0.13	0.07	1.98	1.38	2.83	0.000197*
Fetal (Cases n = 179; Controls n = 628)	F3	rs610277	C	0.10	0.01	2.47	1.31	4.67	0.005
	NPR1	rs3891075	T	0.09	0.07	2.04	1.27	3.30	0.003
	IL6R	rs8192282	A	0.13	0.10	2.07	1.42	3.02	0.000148*
	TNR	rs2228359	T	0.41	0.3	1.47	1.14	1.91	0.004
	IL1B	rs1143643	A	0.2	0.23	1.55	1.18	2.03	0.002
	FN1	rs2304573	C	0.62	0.49	0.70	0.54	0.91	0.008
	IL2	rs2069772	G	0.00	0.13	0.53	0.35	0.80	0.003
	FGF1	rs34003	G	0.30	0.42	0.67	0.51	0.87	0.003
	IFNGR1	rs1887415	C	0.04	0.07	0.50	0.32	0.79	0.003
	IGF2	rs3213225	C	0.09	0.36	0.67	0.51	0.89	0.005
	COL4A1	rs16975492	A	0.41	0.27	0.67	0.51	0.89	0.006
	TIMP2	rs2277698	A	0.13	0.14	1.82	1.27	2.62	0.001

None of these markers had statistically significant deviations from HWE in cases or controls.

¹OR is the Odds Ratio for the additive genotypic model

²95% CI is the 95% confidence interval of the Odds Ratio.

^*Significant after FDR correction.