Table 5.
Single SNP associations (0.01 < p < 0.05)
| a. Maternal DNA | ||||||
|---|---|---|---|---|---|---|
| Gene | SNP | A1 | OR | L95 | U95 | P |
| AGTR1 | rs5183 | G | 2.748 | 1.215 | 6.215 | 0.01522 |
| HSPG2 | rs2229489 | A | 1.947 | 1.135 | 3.34 | 0.01559 |
| SELE | rs5356 | C | 1.348 | 1.056 | 1.72 | 0.01641 |
| MMP16 | rs3739382 | T | 2.564 | 1.185 | 5.544 | 0.01675 |
| AGT | rs4762 | T | 1.433 | 1.062 | 1.934 | 0.01854 |
| COL4A2 | rs2296852 | A | 0.5672 | 0.3521 | 0.9137 | 0.01975 |
| LTF | rs1475967 | T | 0.7642 | 0.6093 | 0.9585 | 0.02 |
| COL4A4 | rs3752896 | G | 1.306 | 1.042 | 1.638 | 0.02074 |
| IL18 | rs549908 | C | 1.328 | 1.043 | 1.691 | 0.0212 |
| MMP10 | rs486055 | A | 1.764 | 1.085 | 2.867 | 0.02204 |
| SERPINE1 | GNSC_629203538 | T | 2.397 | 1.131 | 5.081 | 0.02251 |
| THPO | rs2280740 | A | 1.493 | 1.054 | 2.114 | 0.02398 |
| LTF | rs2239692 | G | 1.407 | 1.045 | 1.894 | 0.02442 |
| VEGFC | rs7664413 | A | 0.7468 | 0.575 | 0.9698 | 0.02851 |
| F3 | rs610277 | C | 2.131 | 1.07 | 4.241 | 0.03129 |
| TIMP2 | rs55743137 | C | 1.358 | 1.023 | 1.803 | 0.03435 |
| CRHR2 | rs8192498 | A | 2.51 | 1.051 | 5.996 | 0.03836 |
| IL12B | GNSC_632292870 | G | 2.662 | 1.042 | 6.801 | 0.04081 |
| SELE | rs1076637 | A | 1.278 | 1.008 | 1.619 | 0.04256 |
| REN | rs3730103 | G | 1.663 | 1.017 | 2.72 | 0.04264 |
| IL10 | rs1800872 | A | 1.268 | 1.008 | 1.596 | 0.04267 |
| COL5A2 | rs6750027 | A | 1.324 | 1.009 | 1.738 | 0.04308 |
| MMP10 | rs17860949 | T | 1.454 | 1.011 | 2.091 | 0.04343 |
| HTR2A | rs6314 | T | 0.5693 | 0.3274 | 0.9899 | 0.04594 |
| TBXAS1 | rs3735355 | A | 0.4793 | 0.2323 | 0.9887 | 0.0465 |
| TLR2 | rs5743700 | T | 0.3845 | 0.1499 | 0.9861 | 0.04669 |
| IL1B | rs1143634 | T | 0.7206 | 0.5213 | 0.9961 | 0.0473 |
| THBS4 | rs2241826 | G | 1.32 | 1.003 | 1.738 | 0.0478 |
| LTF | GNSC_617330042 | A | 1.39 | 1.003 | 1.927 | 0.04825 |
| OXTR | GNSC_631469608 | A | 1.575 | 1.003 | 2.473 | 0.04862 |
| b. Fetal DNA | ||||||
|---|---|---|---|---|---|---|
| Gene | SNP | A1 | OR | L95 | U95 | P |
| IL10RA | rs17121493 | G | 1.815 | 1.155 | 2.854 | 0.009803 |
| TIMP2 | rs55743137 | C | 1.494 | 1.097 | 2.033 | 0.01073 |
| TLR1 | rs5743553 | A | 2.728 | 1.252 | 5.946 | 0.01159 |
| COL4A3 | rs1882435 | A | 1.392 | 1.074 | 1.805 | 0.01253 |
| COL4A4 | rs3752896 | A | 0.7424 | 0.5823 | 0.9464 | 0.0162 |
| CETP | rs891144 | T | 1.603 | 1.083 | 2.371 | 0.01821 |
| COL4A2 | rs7338575 | C | 1.369 | 1.055 | 1.778 | 0.01837 |
| SERPINE1 | rs6092 | A | 1.629 | 1.081 | 2.455 | 0.0198 |
| IL4R | rs1029489 | A | 0.7479 | 0.5852 | 0.9559 | 0.02034 |
| AGTR1 | rs5183 | G | 2.555 | 1.151 | 5.673 | 0.02113 |
| NPPA | rs5068 | C | 0.256 | 0.07936 | 0.8259 | 0.0226 |
| HSPG2 | GNSC_634098268 | T | 1.406 | 1.049 | 1.885 | 0.02264 |
| ELN | rs2301995 | A | 1.44 | 1.05 | 1.974 | 0.02347 |
| COL4A2 | rs12873113 | T | 1.45 | 1.045 | 2.011 | 0.02617 |
| IGF2R | rs894817 | A | 1.316 | 1.032 | 1.679 | 0.02698 |
| IRS1 | rs1801278 | A | 1.762 | 1.055 | 2.945 | 0.03053 |
| COL4A3 | rs56326869 | C | 0.1134 | 0.01558 | 0.8255 | 0.03161 |
| COL4A4 | rs3752895 | C | 0.7748 | 0.6118 | 0.9813 | 0.03433 |
| IL9R | GNSC_14430798 | C | 0.4446 | 0.2085 | 0.9483 | 0.03596 |
| LPA | rs4708871 | G | 2.195 | 1.05 | 4.587 | 0.03655 |
| REN | rs3730103 | G | 1.753 | 1.033 | 2.975 | 0.03763 |
| ELN | rs17855988 | C | 1.631 | 1.028 | 2.589 | 0.03784 |
| IL2 | rs2069771 | T | 2.655 | 1.05 | 6.71 | 0.03908 |
| TIMP1 | rs11551797 | T | 0.4538 | 0.2141 | 0.9618 | 0.03924 |
| COL4A5 | rs28465565 | C | 0.4558 | 0.2153 | 0.965 | 0.04006 |
| IL3RA | GNSC_649033887 | A | 0.3728 | 0.1447 | 0.9606 | 0.04104 |
| SERPINC1 | rs677 | C | 1.601 | 1.017 | 2.521 | 0.04197 |
| TNR | rs1385540 | T | 1.37 | 1.01 | 1.858 | 0.04276 |
| IL1R1 | rs3917318 | G | 1.288 | 1.008 | 1.647 | 0.04315 |
| FIGF | GNSC_634828146 | C | 0.4742 | 0.2289 | 0.9824 | 0.04468 |
| IGF2 | rs2230949 | T | 1.568 | 1.01 | 2.434 | 0.04508 |
| F7 | rs6046 | A | 1.382 | 1.004 | 1.901 | 0.04705 |
| COL4A2 | rs391859 | A | 0.7216 | 0.522 | 0.9975 | 0.04827 |
| COL4A6 | GNSC_634841755 | A | 0.4671 | 0.2187 | 0.9975 | 0.04925 |
| COL4A4 | rs1800516 | C | 0.3023 | 0.09162 | 0.9977 | 0.04956 |