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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Health Phys. 2012 Oct;103(4):463–473. doi: 10.1097/HP.0b013e31826386ef

Figure 6. Comparison of histopathologic damage among strains at radiation doses ranging from 7.5 to 17.5 Gy WTLI.

Figure 6

There is significant variation in pathology among strains. A) Lung tissue from C57BL/6J mice appear mostly normal 26 weeks post-WTLI with a single dose of 7.5 Gy, LW: 162 mg. B) Lungs of CBA/J mice display airway congestion (arrowhead), increased alveolar wall thickness, and lymphocytic inflammation (*) 26 weeks post-WTLI (7.5Gy). LW: 168 mg. C) Significant inflammation and edema is observed in the lungs of C57L/J mice after 7.5 Gy (26 weeks post-IR), which is consisted with the elevation in lung weight. Perivascular lymphocytic cuffing (arrowhead) and foamy macrophages (*) are shown. LW: 257 mg. D) Localized alveolar inflammation (arrowhead) is seen in the irradiated lungs of C57BL/6J mice at 26 weeks post-10 Gy WTLI. This is characterized by an increase in alveolar macrophages and thickening of the alveolar walls. LW: 194 mg. E) An organized pneumonia is seen in the lungs of CBA/J mice 26 weeks after 10 Gy WTLI. LW: 171 mg. F) Complete obliteration of the alveoli and airway congestion is seen in the irradiated lung of C57L/J mice after 10 Gy WTLI. Tissue damage is characterized by excessive, contracted fibrosis, alveolar and vascular inflammation, and significant edema. 26 weeks, LW: 342 mg. G) An increase in eosinophilic macrophages (arrowhead) and focal fibrosis (*) is seen 26 weeks-post 12.5 Gy WTLI in C57BL/6J mice. LW: 296 mg. H) Vascular inflammation and collagen deposition are seen in the lungs of CBA/J mice exposed to 12.5 Gy WTLI. 20-week survival, LW: 484 mg. I) Complete fibrotic consolidation of the alveoli 17 weeks post-WTLI with a single dose of 12.5 Gy. LW: 472 mg J) Foamy alveolar macrophages (arrowhead) are seen in the lungs of moribund C57BL/6J mice following WTLI with a single dose of 17.5 Gy. 22-week survival, LW: 356 mg. K) Collagen deposition, increased alveolar wall thickness, and edema/congestion are seen in the lungs of CBA/J mice after 17.5 Gy WTLI. 18-week survival, LW: 420 mg. L) Fibrotic consolidation of the alveoli in the lungs of of C57L/J mice following 17.5 Gy WTLI. 16-week survival, LW: 600 mg. Significant interstitial edema and airway congestion was an overall feature seen in many of the C57L/J mice at all doses. WTLI: whole thorax lung irradiation. LW=lung weight. *15 Gy is not shown.