Table 1. Comparison of radiation dose response for lung injury among murine strains, nonhuman primates, and humans.
| Murine strain |
No. of subjects in study |
Radiation dose |
Percent lethality across all doses |
Mean survival time |
LD50/180 | 95% Confidence Interval |
|---|---|---|---|---|---|---|
| C57BL/6J | 57 | 7.5-17.5 Gy | 35.1 | 162 (±14) days |
13.43 Gy | 12.20-14.69 Gy |
| CBA/J | 55 | 7.5-17.5 | 36.7 | 125.5(±12) days |
13.11 Gy | 12.08-14.21 Gy |
| C57L/J | 60 | 7.5-17.5 Gy | 56.4 | 120 (±17) days |
10.24 Gy | NE |
| NHP # | 46 | 9-12 Gy | 50 | 144.5 days | 10.28 Gy | 9.92-10.67 Gy |
|
No. of subjects |
Radiation doses |
Incidence of pneumonitis |
Time of onset of PN |
TD50/180 |
95% Confidence Interval |
|
| Humans □ | 150 | 0-12.5 Gy | 15% | ~100 days | 10.60 Gy | 9.97-12.05 Gy |
*
NE = not estimable; Lethality for C57L/J mice was 10% at 10 Gy and 100% at 12.5 Gy. Therefore, a precise LD50/180 was not able to be determined due to the steep dose response for lethal lung injury in this strain. The dose-response study is being repeated with tighter incremental windows;
#
Non-human primate (NHP)- Data from Garofalo et al. 2012;
□
Based on probit analysis of data provided in Table 5 of Van Dyke et al 1981, LD=Lethal dose; TD= Tolerated dose; PN = Pneumonitis