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. Author manuscript; available in PMC: 2013 Mar 21.

Published in final edited form as: Biochemistry. 2011 Dec 29;51(1):273–285. doi: 10.1021/bi201143x

Table 1.

AdT Ammonia Tunnel Conserved Residues

GatA Mutagenesis
S. aureus	H. pylori	H. pylori Mutations
T175	T149	T149A, V, S^a
R200	R174	R174A^b, K
S208	S182	S182A, T
D211	D185	D185A, N
R323	R295	R295A, K

GatB Mutagenesis
S. aureus	H. pylori	H. pylori Mutations
R78	R79	R79A, K
K79	K80	K80A^a, R
Y81	Y82	Y82A, F
K88	K89	K89A, R
Y90	Y91	Y91A, F
Q91	Q92	Q92A, E
E125	E125	E125A, D, Q
E272^c	D276	D276A, N
D274	D278	^*

^a

Site-directed mutagenesis was not successful.

^b

Mutant could not be purified to homogeneity.

^c

Residue is not rigorously conserved, but is typically glutamic or aspartic acid.

^*

Not analyzed.