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. Author manuscript; available in PMC: 2013 Mar 21.
Published in final edited form as: Trends Cell Biol. 2002 Feb;12(2):72–78. doi: 10.1016/s0962-8924(01)02203-6

Figure 1.

Figure 1

Replication licensing and CDK activity through the cell cycle.

A small segment of chromosomal DNA is depicted at different cell cycle stages, with bound (red hexagons, M) or unbound (blue hexagons, M) Mcm2-7. The activity of the replication licensing system (RLS, purple) and cyclin-dependent kinases (CDK, green) at the different stages are show in the central circle. Inset, the sequence of events occurring as each origin binds Mcm2-7 and becomes licensed. The loading of ORC (purple), Cdt1 (yellow) and Cdc6 (green), and then Mcm2-7 (red, M) is shown. At some time after licensing is complete, ORC, Cdc6 and Cdt1 may become inactivated, as indicated by grey shading.