Figure 5.

Inhibition of the antinociceptive effect of capsaicin/QX-314 by capsazepine.

Notes: Capsazepine (50 μg/mL; 10 μL) was injected 30 minutes prior to the capsaicin/QX-314 (10 μL) injection (capsazepine/capsaicin/QX-314 group) into rat right plantar hind paws. The capsaicin/QX-314 group showed a longer withdrawal latency than the capsazepine/capsaicin/QX-314 group, the QX-314 group, or the vehicle group at 60 to 300 minutes (P < 0.01, P < 0.001). The capsazepine/capsaicin/QX-314 group did not differ significantly from the vehicle group.

Abbreviation: QX-314, N-ethyl-lidocaine.