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. 2013 Mar 16;6:223–230. doi: 10.2147/JPR.S41614

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© 2013 Nakagawa and Hiura, publisher and licensee Dove Medical Press Ltd

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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Effect on uptake of the fluorescence tracer (FAM). The fluorescence in small neurons (arrows) was conspicuous in DRGs injected with capsaicin and QX-314-FAM (A). Fluorescence was not detected in DRGs injected with only QX-314-FAM (B), AITC/QX-314-FAM (C), and menthol/QX-314-FAM (D).

Abbreviations: AIT, allyl isothiocyanate; DRG, dorsal root ganglia; FAM, 5(6)-carboxyfluorescein; QX-314, N-ethyl-lidocaine; TRPA1, transient receptor potential ankyrin 1; TRPM8, transient receptor potential melastatin-8; TRPV1, transient receptor protein vanilloid 1.