Table 4.

Cox proportional hazards regression model for recurrence following immediate and delayed RP based on CaPSURE data and for prostate cancer death based on T-stage ≤ T2a JH-PCM data. The immediate RP model was fit to 2,150 cases with low-risk disease (T-stage ≤ T2a, Gleason score ≤ 6, and PSA level ≤ 10 ng/mL); the delayed RP model, used to simulate times to recurrence following AS, was fit to 3,470 cases with T-stage ≤ T2a disease.

End Point	Covariate	Coefficien	Hazard ratio	95% CI	p-value
Recurrence under immediate RP	Age	0.01	1.01	(0.98, 1.03)	0.527
(Fit to low-risk CaPSURE cohort)	PSA	0.15	1.16	(1.07, 1.25)	< 0.001
Recurrence under delayed RP	Age	0.01	1.01	(1.00, 1.03)	0.187
(Fit to T-stage ≤ T2a CaPSURE cohort)	PSA	0.03	1.03	(1.02, 1.03)	< 0.001
	Gleason score
	≤ 6	ref
	7	0.47	1.59	(1.25, 2.03)	< 0.001
	≥ 8	1.43	4.16	(2.92, 5.93)	< 0.001
Prostate cancer mortality	Time to recurrence	−0.44	0.65	(0.51, 0.82)	< 0.001
	Gleason score
	≤ 6	ref
	7	0.56	1.75	(0.96, 3.17)	0.066
	≥ 8	0.89	2.43	(1.21, 4.86)	0.012