Table 1. Model parameters.

Blood parameters
Maximal RBC oxygen concentration	C 0 = 0.5 cm3O2 cm−3	[24]
Effective unbound oxygen solubility	αeff = 3.1×10−5 cm3O2 cm−3 mmHg−1	[24]
Hill equation parameter	P 50 = 38 mmHg	[24]
Hill equation parameter	n = 3	[24]
Tissue oxygen parameters
Krogh diffusion constant	DO α = 6×10−10 cm3O2 cm−1 s−1 mmHg−1	[24]
Consumption rate	M 0 = 0.5–2.5 cm3O2 (100 cm3)−1 min−1	See text
PO 2 at half-maximal consumption	Pc = 1 mmHg	[24]
VEGF parameters
Diffusivity	DG = 1.13×10−6 cm2 s−1	[51]
Basal release rate	MG 0 = 1.97×10−3 pM s−1	[51]
Tissue degradation rate constant	KG = 2.82×10−3 s−1	See text
Structural adaptation parameters
Reference wall shear stress	τref = 0.103 dyn/cm2	[20]
Reference oxygen level for metabolic signal	PO 2ref = 93.2 mmHg	[20]
Conducted response length constant	Lc = 17300 µm	[20]
Reference flow rate for metabolic signal	Qref = 0.198 nl/min	[20]
Conducted response saturation	J 01 = 1000 µm	See text
Pressure sensitivity	kp = 0.68	[20]
Metabolic sensitivity	kp = 0.70	[20]
Conducted response sensitivity	kc = 2.45	[20]
Shrinking tendency	ks = 2.549	See text
Randomization of shrinking tendency	Ran-ks = 0.1	[47]
Structural adaptation time scale	T = 4.5 day	[46]
Angiogenesis parameters
Time step	Δt = 1 day
Diameter of new sprouts	Ds = 10 µm	[25]
Threshold VEGF concentration	Cth = 0.8 nM	See text
Constant in sprouting probability function	Cth 50 = 0.5 nM	See text
Maximum sprout formation probability	kp = 0.002 µm−1 day−1	[12]
Sprout growth rate	Vg = 50 µm day−1	[39]
Attraction constant to nearby vessels	kV = 10 µm−1	See text
Maximum vessel sensing distance	Rmax = 100 µm	[41]
Maximum vessel sensing angle	θmax = π/3	See text
Variance of growth direction randomization	σs = 0.1	See text
Vessel migration parameters
Threshold for migration	λt = 0.05	See text
Maximum migration velocity	vmax = 1 µm day−1	See text