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. 2013 Mar 21;9(3):e1003397. doi: 10.1371/journal.pgen.1003397

Figure 8. A speculative two-step model in which NM1 bridges the pol I machinery and chromatin via an interaction with SNF2h that competes with actin.

Figure 8

(I) NM1 interacts with polymeric actin and with the rDNA via its C-terminus, generating local force that pulls the polymerase along active gene. (II) Upon NM1 dissociation from actin, NM1 interacts with SNF2h in a WSTF-dependent manner, a mechanism that provides a way to stabilize the WICH complex on the rDNA, to recruit PCAF, and to maintain the levels of H3K9 acetylation required for transcription activation.