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. 2013 Mar 21;9(3):e1003403. doi: 10.1371/journal.pgen.1003403

Figure 3. Cv-C mediates PCV morphogenesis downstream of BMP signaling by inactivating various Rho-type small GTPases.

Figure 3

(A) Adult wing of cv-c1. (B, C) Optical cross-sections of the PCV region. F-actin (B) and ß-integrin (C) staining at 24 hr AP in cv-c1. (D—H) in situ hybridization of cv-c at 20 hr AP (D) and at 24 hr AP (E) in wild-type yw, and at 20 hr AP (F) and at 24 hr AP (G) in cv70, and at 24 hr AP in BS1348>caTkv (H). BS1348-Gal4 is intervein-specific Gal4 driver. (I) Genetic interactions of cv-c with various small GTPases. Representative adult wings around the PCV region of each genotype are shown above. (J, K) pMad staining at 24 hr AP in wild-type yw (J) and in cv70, cdc422 double mutant (K). (L—L″) Optical cross-sections of the PCV region. pMad (L), F-actin (L′), and ß-integrin (L″) staining at 24 hr AP in cv70, cdc422 double mutant. (M) A schematic pathway regulating PCV morphogenesis downstream of BMP signaling.