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. 2013 Mar 21;9(3):e1003403. doi: 10.1371/journal.pgen.1003403

Figure 6. Sog-Cv-dependent BMP signaling is induced along ectopic wing vein morphogenesis by loss of cdc42.

Figure 6

(A) Adult wing of cdc422. (B, B′) pMad (B) and lacZ staining (B′) in cdc422 ; dppshv-lacZ/+. (C—F) pMad staining (C, E) and adult wing (D, F) of sogP129D, cdc42 2 (C, D) and cv70, cdc42 2 (E, F). (G) Quantification of the phenotypes in A, D and F. (H—K) Optical cross-sections of the ectopic CV region (white arrows in B and C). pMad and F-actin (H, J) and ß-integrin (I, K) staining in cdc422 (H, I) and sogP129D, cdc42 2 (J, K). The relative ß-integrin accumulation at the basal side of the ectopic CV region by comparing to that of intervein regions is 32±2% (n = 7 wings) in cdc422 (I) and 37±3%, (n = 6 wings) in sog, cdc42 (K). (L, M) pMad staining and adult PCV (inset) in sogP11885 (L) and in sogP11885, cdc422 (M). (N) Quantification of the adult wing phenotypes in L and M. All pupal wings were fixed at 24 hr AP.