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. 2013 Jan 18;10:8. doi: 10.1186/1742-4690-10-8

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Copyright ©2013 Gall et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Correlation of the Shannon Entropy with clinical markers of HIV infection. The correlation with (a) the time after seroconversion, (b) the viral load, and (c) the CD4 cell count is shown for 30 subjects at primary infection with HIV. As the time to seroconversion is not known for subject 15, it is not included in (a). Patients were classified into three groups based on the sequence diversity. Group 1 is defined by a low sequence diversity (Shannon Entropy 0–0.75) and is shown as stars. Group 2 is defined by a medium sequence diversity (Shannon Entropy 0.75–1.5) and is shown as triangles. Group 3 is defined by a high sequence diversity (Shannon Entropy > 1.5) and is shown as dots.