Table 2. Sample size calculations for superiority trials.
Control treatment Success Rate | Test treatment Success Rate | Power | N Per Group |
0.6 | 0.7 | 0.80 | 356 |
0.6 | 0.7 | 0.85 | 407 |
0.6 | 0.7 | 0.90 | 477 |
0.6 | 0.7 | 0.95 | 589 |
0.6 | 0.8 | 0.80 | 82 |
0.6 | 0.8 | 0.85 | 93 |
0.6 | 0.8 | 0.90 | 109 |
0.6 | 0.8 | 0.95 | 134 |
0.6 | 0.9 | 0.80 | 32 |
0.6 | 0.9 | 0.85 | 36 |
0.6 | 0.9 | 0.90 | 42 |
0.6 | 0.9 | 0.95 | 52 |
0.65 | 0.7 | 0.80 | 1377 |
0.65 | 0.7 | 0.85 | 1575 |
0.65 | 0.7 | 0.90 | 1842 |
0.65 | 0.7 | 0.95 | 2278 |
0.65 | 0.8 | 0.80 | 138 |
0.65 | 0.8 | 0.85 | 158 |
0.65 | 0.8 | 0.90 | 185 |
0.65 | 0.8 | 0.95 | 228 |
0.65 | 0.9 | 0.80 | 43 |
0.65 | 0.9 | 0.85 | 49 |
0.65 | 0.9 | 0.90 | 57 |
0.65 | 0.9 | 0.95 | 70 |
0.7 | 0.8 | 0.80 | 294 |
0.7 | 0.8 | 0.85 | 336 |
0.7 | 0.8 | 0.90 | 392 |
0.7 | 0.8 | 0.95 | 485 |
0.75 | 0.8 | 0.80 | 1094 |
0.75 | 0.8 | 0.85 | 1251 |
0.75 | 0.8 | 0.90 | 1464 |
0.75 | 0.8 | 0.95 | 1810 |
0.75 | 0.9 | 0.80 | 100 |
0.75 | 0.9 | 0.85 | 114 |
0.75 | 0.9 | 0.90 | 133 |
0.75 | 0.9 | 0.95 | 164 |
0.8 | 0.9 | 0.80 | 199 |
0.8 | 0.9 | 0.85 | 228 |
0.8 | 0.9 | 0.90 | 266 |
Efficacy in the reference arm from 60–80%, delta 10–30%, alpha error 0.05, power 80–95%.