Figure 1.

The difference between classic approach and the KDVS approach. Illustration of the difference between classic enrichment–based approach and the KDVS framework approach. In classic, monolithic gene expression data are mined for significant genes and prior biological knowledge is used a posteriori to verify the soundness of result. This approach is sensitive to the choice of mining technique, as well as the enrichment verification method. In KDVS, monolithic gene expression data are transformed according to prior knowledge (e.g. divided in smaller parts accordingly), and then mined for significant genes. This approach enables wider choice of mining techniques and provides biological insight before the core mining step.