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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Heart Rhythm. 2012 Dec 12;10(4):592–599. doi: 10.1016/j.hrthm.2012.12.016

Figure 7. CaMKII inhibition suppresses SCaW in mdx ventricular myocytes at 3-Hz.

Figure 7

(A) Representative tracings showing spontaneous Ca2+ waves (SCaW) following 3-Hz pacing. CaMKII inhibitor KN-93 (1 μM) or PKA inhibitor H-89 (1 μM) were added subsequently, followed by another observation period for SCaWs. Scale bars: 2 F/F0 (vertical) and 20 seconds (horizontal). (B) Bar graph showing SCaW frequency after inhibitor administration normalized to SCaW frequency in Tyrode.