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. Author manuscript; available in PMC: 2013 Mar 21.
Published in final edited form as: Cancer Cell. 2007 Nov;12(5):479–491. doi: 10.1016/j.ccr.2007.10.017

Figure 1. p16 overexpression coupled with proliferation increases the risk of subsequent tumor events among women with DCIS.

Figure 1

A) Representative p16 immunohistochemistry.

B) High p16 staining fails to stratify women with DCIS that develop subsequent disease. Recurrence-free survival plots demonstrate that women with DCIS staining high or low for p16 develop subsequent disease at the same rate.

C) Ki67 index labelling stratifies recurrence-free survival in women with DCIS.

D) DCIS exhibiting high p16 immunostaining and elevated Ki67 identifies women that have a reduced recurrence-free survival.

E) Ki67 does not differentiate risk in DCIS lesions with low p16. Box plots and corresponding p-values were determined using Wilcoxon/Kruskal-Wallis rank of sums test. Survival plots were generated using Kaplan-Meyer analysis.