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. Author manuscript; available in PMC: 2013 Mar 21.
Published in final edited form as: Cancer Cell. 2007 Nov;12(5):479–491. doi: 10.1016/j.ccr.2007.10.017

Figure 2. High p16 mRNA defines the basal-like subtype of invasive tumors.

Figure 2

A) Unsupervised hierarchical clustering of 130 invasive tumors using 589 unique genes that are intrinsically variable (see Supplemental File 1) identifies luminal A, luminal B, normal-like, HER2 positive and basal-like clusters. Molecular subtypes, additionally classified by a nearest centroid approach are indicated by coloured bars (light blue: Luminal B; dark blue: Luminal B; green: Normal-like; orange: Basal-like; pink: HER2 positive tumors; grey: Unclassified).

B) Expression levels of p16, Rb, E2F3, cyclin E1, cyclin D1 and COX-2. The level of expression of each gene is relative to the median across all samples as represented by color saturation.