Simulated z-spectra, NOE signals, and APT signals of the WM at several power levels. All these simulations were done using the mean fitted parameters of the WM for all five volunteers. a: Z-spectra from the four-pool model (bulk water protons, solid-like macromolecular protons, APT-related amide protons, and NOE-related protons). b: Z-spectra from the two-pool model (bulk water protons and solid-like macromolecular protons). c: Z-spectra from the first three-pool model (bulk water protons, solid-like macromolecular protons, and APT-related amide protons). No NOE effects can be seen. d: Z-spectra from the second three-pool model (bulk water protons, solid-like macromolecular protons, and NOE-related protons). No APT effects can be seen. e: (b) - (a). Both NOE and APT signals are observed. f: (c) - (a). Only NOE signals are observed. g: (d) - (a). Only APT signals are observed.