Table 2.
Top 5 LD-independent signals in the primary European-derived TS meta-analysis.
| CHR | SNP | BP | A1/ A2 |
Primary European Meta-analysis |
# SNPs in LD1 |
Annotation | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF | OR | p-value | Gene | Left Gene | Right Gene | eQTL | Cerebellar mQTL | |||||
| 9 | rs7868992 | 116030892 | G/ A |
0.28 | 1.29 | 1.85 ×10−6 | 1 | COL27A1 (intron) |
KIF12 | ORM1 | - | SYTL4, AMBP, HSPC152, OAS2, PWP1, RALBP1 |
| 12 | rs6539267 | 105309684 | C/T | 0.31 | 0.79 | 7.41 ×10−6 | 0 | POLR3B (intron) |
TCP11L2 | FLJ45508 | - | TMEM119 |
| 3 | rs13063502 | 110707002 | T/C | 0.14 | 1.35 | 8.96 ×10−6 | 0 | - | FLJ25363 | LOC440973 | - | - |
| 13 | rs7336083 | 84901388 | A/ G |
0.34 | 0.80 | 9.49 −10−6 | 2 | - | LOC 387939 |
SLITRK6 | SLITRK6 (cerebellum) |
SORT1, ARFGAP1, CSN3 |
| 7 | rs769111 | 12026331 | G/T | 0.38 | 0.81 | 1.20 −10−5 | 4 | - | THSD7A | TMEM106B | MEOX2 (cerebellum) |
PLSCR1, PCDHB16 |
CHR, chromosome; BP, hg19 position; A1, reference allele; A2, alternative allele; MAF, minor allele frequency; OR, odds ratio;
1
# SNPs in LD, number of additional SNPs in linkage disequilibrium (LD) with association p-values <1 ×10−3 in the primary meta-analysis (LD defined as r2>0.5). Complete annotation of these SNPs as well as all SNPs with association p-values <1×10−3 are provided in Supplementary Table S2.