Table 3.
GO biological process terms of 17 differentially expressed genes mapped to the hallmarks of cancer
| Gene/cancer hallmark | HM1 | HM2 | HM3 | HM4 | HM5 | HM6 | HM7 | HM8 | HM9 | HM10 |
|---|---|---|---|---|---|---|---|---|---|---|
|
KLK6 |
|
GC |
|
|
G, GC |
|
|
|
|
G, GC |
|
IRAK1 |
|
GC |
|
GC |
|
|
|
GC |
|
GC |
|
CDC7 |
G |
G,GC |
|
G, GC |
|
|
GC |
G |
|
|
|
CHEK1 |
G |
G |
|
G |
|
|
G, GC |
G |
|
|
|
BUB1 |
|
|
|
G |
|
|
GC |
|
|
|
|
CHEK2 |
|
|
|
G, GC |
|
|
G, GC |
|
|
|
|
STC2 |
GC |
GC |
L |
L |
|
|
|
|
|
|
|
DAB2 |
GC |
|
|
G, GC |
GC |
|
|
GC |
|
|
|
VIM |
|
|
GC |
|
|
GC |
|
|
|
|
|
FOXL2 |
|
|
|
GC |
GC |
GC |
GC |
|
|
|
|
LCN2 |
|
|
L |
|
|
L |
|
|
|
|
|
PGR |
GC |
|
|
|
|
|
|
|
|
|
|
AR |
GC |
GC |
|
G, GC |
|
|
|
|
|
|
|
IGF1R |
|
G, GC |
G, GC |
G, GC |
|
G, GC |
|
G |
GC |
|
|
LYN |
GC |
|
GC |
GC |
|
GC |
GC |
|
GC |
|
|
IGFBP7 |
G, GC |
G |
|
G, GC |
|
|
|
G |
|
|
| CLU | GC | GC | GC |
HM1: sustain growth signal, HM2: escape growth suppressor i.e. insensitivity to growth inhibitor, HM3: active invasion and metastasis, HM4: limitless replicative potential/enable replicative immortality, HM5: induce angiogenesis, HM6: resist cell death, HM7: cause genomic instability, HM8: deregulate cellular energetic, HM9: avoid immune destruction, HM10: tumor promoting inflammation, G: GATHER [71], GC: GeneCards [72], L: literature (G details in Additional file 8 and GC and L details in Additional file 9).