Table 2.
Predictors of persistent GH deficiency: all patients (n = 73)
| History of organic disease | ≥2 extra PHDs | ≥1 extra PHD | IGF-I < -5.3 SDS | IGF-I < -3.0 SDS | IGF-I < -2.0 SDS | ≥1 extra PHD and IGF-I < -2.0 SDS | IGFBP-3 < -2.0 SDS | |
|---|---|---|---|---|---|---|---|---|
|
Positive Predictive Value (%) |
100 |
100 |
96 |
100 |
84 |
65 |
100 |
100 |
|
Negative Predictive Value (%) |
64 |
66 |
76 |
71 |
83 |
84 |
75 |
59 |
|
Specificity (%) |
100 |
100 |
97 |
100 |
83 |
46 |
100 |
100 |
| Sensitivity (%) | 47 | 53 | 71 | 63 | 84 | 92 | 68 | 37 |
Abbreviations: IGF-I = insulin-like growth factor I, IGFBP-3 = insulin-like growth factor binding protein 3, n = number, PHD = pituitary hormone deficiency, SDS = standard deviation score.