Table 3.
Predictors of persistent GH deficiency in patients with history of idiopathic GH deficiency (n = 55)
| ≥1 cextra PHD | ≥2 extra PHD | IGF-I < -5.3 SDS | IGF-I < -4.0 SDS | IGF-I < -3.0 SDS | IGF-I < -2.0 SDS | IGF-I > -1.6 SDS | IGFBP-3 < -2.0 SDS | Age <4 yr at original Dx | ≥1 PHD + IGF-I < -2.0 SDS | IGF-I < -2.0 SDS + age <4 yr at original Dx | |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Positive Predictive Value (%) |
93 |
100 |
100 |
81 |
73 |
53 |
49 |
100 |
89 |
100 |
100 |
|
Negative Predictive Value (%) |
83 |
78 |
79 |
82 |
88 |
94 |
100 |
73 |
76 |
83 |
75 |
|
Specificity (%) |
97 |
100 |
100 |
91 |
82 |
50 |
38 |
100 |
97 |
100 |
100 |
| Sensitivity (%) | 65 | 50 | 55 | 65 | 80 | 95 | 100 | 35 | 42 | 65 | 40 |
Abbreviations: Dx = diagnosis, GH = growth hormone, IGF-I = insulin-like growth factor I, n = number, PHD = pituitary hormone deficiency, SDS = standard deviation score, yr = year.