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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Cytokine Growth Factor Rev. 2012 Nov 16;24(2):115–121. doi: 10.1016/j.cytogfr.2012.10.001

Figure 1. The IL-27 and IL-27 receptor.

Figure 1

Schematic representation of IL-27 and the IL-27 receptor complex, demonstrating a significant homology with other IL-12 receptor family members. IL-27 shares Ebi3 with IL-35 whilst p28 may signal on its own or form complexes with CLF-1. IL-27 receptor complex shares gp130 with IL-35 and IL-6 receptors. IL-12Rβ2 is shared among IL-12, IL-23, and IL-35 receptors further increasing the possibility of signaling complexes.