Figure 2. The PPARβ/δ agonist GW0742 increases protein degradation and induces atrophy of cultured L6 myotubes.

A) Protein degradation (% per 24 h) in myotubes treated for 24 h with 0.1 µM GW0742 or vehicle (Ctr). B) Morphology of cultured L6 myotubes after treatment for 24 h with 0.1 µM GW0742 or vehicle (Ctr). Myotubes were photographed under a phase contrast microscope at 100× magnification. C) Diameter of cultured myotubes after treatment for 24 h with 0.1 µM GW0742 or vehicle (Ctr). Results are means ± SEM with n = 8/group.*p<0.05 vs control.