Table 1.

Demographics of the 81 subjects with surfactant associated disorders

	n.	%
Classification
Primary PAP
Idiopathic + autoimmune1	73	90
Hereditary2	1	1
Secondary PAP3	3	4
PAP-like4	4	5
Gender
Male	54	66.5
Female	27	33.5
Smoking status
Current	18	22
Former	34	42
Never	29	36

¹ We began to measure serum GMAb level in 2004, thus for accuracy in this group we included patients with idiopathic PAP (n = 42, those diagnosed before 2004) and patients with autoimmune PAP (n = 31, those diagnosed after 2004), although currently they are considered synonymous. ² This subject was affected by PAP due to a GM-CSF receptor αchain mutation [17]. ³ This group includes two subjects with PAP secondary to hematologic disorders (1 chronic myeloid leukemia and 1 myelodysplastic syndrome) and 1 subject affected by lysinuric protein intolerance (the latter’s case history has already been reported) [18,19]. ⁴ This group includes four subjects with a mutation in the ABCA3 gene (manuscript in preparation).