Table 2.
Characteristics and assessment of the PAP cohort
| |
n. |
% |
m ± sd |
|---|---|---|---|
| 73 | |||
|
Age |
|
|
41 ± 12.8 (yrs) |
|
Gender |
|
|
|
| Male |
52 |
71 |
|
| Female |
21 |
29 |
|
|
Smoking status |
|
|
|
| Current |
16 |
22 |
|
| Former |
33 |
45 |
|
| Never |
24 |
33 |
|
|
Exposures1 |
26 |
36 |
|
|
Symptoms at enrollment |
|
|
|
| Symptomatic |
69 |
95 |
|
| dyspnea2 |
49 |
67 |
|
| cough |
23 |
31 |
|
| fever |
8 |
11 |
|
| sputum production |
1 |
1 |
|
| Asymptomatic |
4 |
5 |
|
|
Diagnostic procedures3 |
69 |
|
|
| HR CT Scan |
51 |
74 |
|
| Biopsy |
41 |
56 |
|
| BAL |
32 |
46 |
|
| GMAbs4 |
31 |
45 |
|
|
Infection at enrollment4 |
14 |
19 |
|
|
Lung Function5 |
|
|
|
| FVC |
57 |
|
75.50 ± 21.1 (% predicted) |
| FEV1 |
57 |
|
77.77 ± 18.49 (% predicted) |
| TLC |
57 |
|
75.38 ± 14.77 (% predicted) |
| DLCO |
57 |
|
51.83 ±17.90 (% predicted) |
| PaO2 |
57 |
|
64.46 ± 14.17 (mm Hg) |
| ΔA-aO2 |
57 |
|
41.44 ± 16.25 (mm Hg) |
| Exercise Sat.O2 |
57 |
|
-4.27% ± 1.93 |
|
Biomarkers 6 |
|
|
|
| Cyfra 21-1 |
26 |
|
12.8 ± 14.6 (ng/mL) (nv: 0.0-3.3) |
| CEA |
27 |
|
13.4 ± 13.4 (ng/mL) (nv: 0.0-5.0) |
| NSE |
23 |
|
20.04 ± 6.9 (ng/mL) (nv: 0.0-15.0) |
| LDH |
57 |
|
550.3 ± 248 (U/L) (nv: 230-460) |
| GMAbs |
31 |
|
184.1 ± 175 (μg/ml) (nv < 3) |
|
DSS 7 |
39 |
|
|
| 1 |
2 |
5 |
|
| 2 |
12 |
31 |
|
| 3 |
13 |
33 |
|
| 4 |
4 |
10 |
|
| 5 | 8 | 21 |
1Subjects exposed for work-related reasons to dust, smoke or gas of organic or inorganic origin. 2Patients may report more than one symptom.3No data available in 4/73 pts. More than one diagnostic tool was applied in 58 PAP patients (84%). Measurement of GMAbs began in 2004.4These include respiratory infections in 12 patients (4 Staph.aureus, 3 Str.pneumoniae, 1 Pn.jiroveci, 1 Kleb.pneumoniae, 1 Nocardia ast., 1 Serratia Marcesc., 1 Candida Alb) and 2 isolates of H.pilorii from gastric biopsy. 5Abbreviation legends: FVC: forced vital capacitiy; FEV1: forced expiratory flow in the first second; TLC: total lung capacity; DLCO: diffusing lung capacity for carbon monoxide; PaO2: arterial oxygen tension; ΔA-aO2: alveolar to arterial oxygen tension difference;%predicted: percentage of the predicted value; nv: normal value. 6Abbreviation legends: Cyfra 21-1: cytokeratin 19 fragment 21-1; CEA: carcinoembrionic antigen; NSE: neuron specific enolase; LDH: lactate dehydrogenase. 7 DSS: disease severity score [10].