Table 2.
Independent associations between risk factors and desaturase activities in 5 lipid pools in regression models that also included African Caribbean ethnicity and Asian Indian ethnicity (partial correlation coefficients)
| BMI | Waist | Waist hip ratio | Systolic BP | Diastolic BP | Chol | Trig | HDL chol | Glucose | HOMA-IS | |
|---|---|---|---|---|---|---|---|---|---|---|
|
Stearoyl-CoA desaturase C16 | ||||||||||
| FF |
0.20† |
0.16* |
0.00 |
0.09 |
0.04 |
−0.07 |
0.06 |
0.00 |
0.04 |
0.00 |
| TG |
0.09 |
0.05 |
−0.01 |
0.07 |
0.04 |
−0.06 |
0.09 |
−0.01 |
−0.01 |
0.07 |
| CE |
0.29 § |
0.26§ |
0.22† |
0.07 |
0.01 |
0.14 |
0.39§ |
−0.10 |
0.10 |
−0.03 |
| PL |
0.27 § |
0.18* |
−0.02 |
0.12 |
0.06 |
0.03 |
0.20† |
0.01 |
0.12 |
−0.09 |
|
Stearoyl-CoA desaturase C18 | ||||||||||
| FF |
0.21† |
0.18* |
0.06 |
0.11 |
0.14 |
−0.13 |
0.02 |
−0.02 |
0.09 |
−0.03 |
| TG |
−0.11 |
−0.15* |
−0.12 |
−0.01 |
0.01 |
−0.08 |
−0.03 |
−0.05 |
−0.03 |
0.11 |
| CE |
−0.07 |
−0.07 |
0.09 |
0.00 |
−0.05 |
0.05 |
0.01 |
0.01 |
−0.03 |
0.14 |
| PL |
0.01 |
−0.05 |
−0.08 |
0.09 |
0.01 |
−0.13 |
−0.17* |
0.13 |
−0.04 |
0.03 |
|
n-6 Δ-6 desaturase | ||||||||||
| FF |
0.01 |
0.07 |
0.04 |
0.05 |
0.08 |
−0.05 |
0.05 |
−0.09 |
−0.02 |
−0.08 |
| TG |
0.10 |
0.12 |
0.12 |
−0.01 |
−0.04 |
0.16* |
0.10 |
0.11 |
0.04 |
−0.13 |
| CE |
0.26§ |
0.23† |
0.12 |
−0.02 |
0.01 |
0.03 |
0.28§ |
−0.19† |
−0.04 |
−0.12 |
| PL |
0.20† |
0.18* |
0.14 |
0.06 |
−0.10 |
0.11 |
0.32§ |
−0.17* |
−0.06 |
0.11 |
|
n-6 Δ-5 desaturase | ||||||||||
| FF |
−0.02 |
−0.01 |
−0.01 |
0.00 |
0.07 |
0.14 |
0.12 |
0.14 |
0.01 |
0.03 |
| TG |
0.03 |
−0.02 |
−0.08 |
0.11 |
0.16* |
−0.17* |
−0.35§ |
0.13 |
−0.04 |
0.25§ |
| CE |
−0.12 |
−0.13 |
−0.15* |
0.15 |
0.12 |
0.02 |
−0.11 |
0.15* |
0.20† |
0.04 |
| PL |
−0.22† |
−0.21† |
−0.21† |
−0.01 |
−0.06 |
−0.16* |
−0.37§ |
0.24† |
0.06 |
0.01 |
|
n-3 Δ desaturase | ||||||||||
| FF |
0.00 |
0.04 |
−0.01 |
−0.07 |
−0.05 |
0.06 |
0.14 |
−0.02 |
−0.10 |
−0.08 |
| TG |
0.14 |
0.12 |
0.07 |
−0.04 |
0.01 |
−0.03 |
−0.08 |
0.02 |
−0.08 |
0.12 |
| CE |
0.05 |
−0.01 |
0.13 |
−0.08 |
−0.11 |
0.04 |
−0.14 |
0.22† |
−0.04 |
−0.08 |
| PL |
−0.08 |
−0.02 |
0.09 |
0.02 |
−0.11 |
0.09 |
−0.04 |
0.16* |
−0.03 |
−0.12 |
| African Caribbean |
0.24†–0.34 § |
0.18*–0.32 § |
0.09–0.22† |
0.15–0.20* |
0.22†–0.27† |
−0.07–0.04 |
−0.13–0.11 |
−0.02–0.08 |
−0.02–0.07 |
−0.22†–−0.13 |
| Asian Indian | 0.06–0.14* | 0.01–0.08 | −0.05–0.20† | −0.10–−0.01 | −0.02–0.03 | 0.04–0.15* | 0.20†–0.40§ | −0.34§–−0.21† | −0.02–0.02 | −0.03–0.07 |
Abbreviations: TF total fatty acids; FF free fatty acids; TG triglycerides; CE cholesterol esters; PL phospholipids. Significances: * p < 0.05 (borderline); † p < 0.01; § p < 0.001.