Table 3.
Product: precursor ratio desaturase activities in 5 lipid pools with effects of African Caribbean and Asian Indian ethnicity relative to White European derived from linear regression models incorporating ethnicity and potential confounding variables
| White European n = 89 (median, IQ range) | African-Caribbean n = 53 (coefficient, 95%CI) | Asian Indian n = 56 (coefficient, 95%CI) | |
|---|---|---|---|
|
Stearoyl-CoA desaturase C16 | |||
| FF |
0.15 (0.12,0.20) |
−0.05 (−0.07,−0.04) § |
−0.04 (−0.05,−0.02) § |
| TG |
0.17 (0.14,0.20) |
−0.04 (−0.05,−0.03) § |
−0.03 (−0.04,−0.02) § |
| CE |
0.25 (0.20,0.30) |
−0.08 (−0.10,−0.04) § |
−0.06 (−0.09,−0.03) § |
| PL |
0.02 (0.02,0.03) |
−0.007 (−0.010,−0.004) § |
−0.005 (−0.008,−0.002) § |
|
Stearoyl-CoA desaturase C18 | |||
| FF |
3.8 (3.0,5.0) |
−0.14 (−0.24,0.03) * |
−0.06 (−0.17,0.05) |
| TG |
11.3 (9.7,13.8) |
−0.23 (−0.36,−0.09) † |
−0.15 (−0.30,−0.01) * |
| CE |
20.3 (16.8,23.5) |
−0.13 (−0.24,−0.02) * |
−0.09 (−0.21,,0.03) |
| PL |
0.84 (0.73,0.94) |
−0.13 (−0.17,−0.09) § |
−0.13 (−0.16,−0.09) § |
|
n-6 Δ-6 desaturase | |||
| FF |
0.00 (0.00,0.01) |
0.003 (−0.002,0.008) |
−0.002 (−0.007,0.004) |
| TG |
0.01 (0.01,0.02) |
0.001 (−0.002,0.005) |
0.002 (−0.002,0.006) |
| CE |
0.01 (0.01.0.01) |
−0.001 (−0.002,0.001) |
−0.003 (−0.004,−0.001) † |
| PL |
0.09 (0.07,0.11) |
−0.010 (−0.021,−0.001) * |
−0.025 (−0.036,−0.014) § |
|
n-6 Δ-5 desaturase | |||
| FF |
2.1 (0.0,12.5) |
0.16 (−0.31,0.62) |
0.51 (0.00,1.01) * |
| TG |
4.4 (3.2,5.5) |
0.17 (−0.01,0.35) |
0.01 (−0.19,0.20) |
| CE |
8.9 (7.4,10.8) |
0.29 (0.13,0.45) † |
0.14 (−0.04,0.32) |
| PL |
2.9 (2.2,3.5) |
0.13 (0.04,0.22) † |
0.12 (0.02,0.22) * |
|
n-3 Δ desaturase | |||
| FF |
0.00 (0.00,0.20) |
0.22 (−0.00,0.44) |
−0.10 (−0.34,0.10) |
| TG |
0.18 (0.11,0.30) |
0.16 (0.03,0.29) * |
0.09 (−0.05,0.23) |
| CE |
1.28 (0.92,1.79) |
0.12 (−0.30,0.55) |
0.28 (−0.18, 0.75) |
| PL | 2.78 (1.79,4.43) | −0.03 (−0.33,0.26) | −0.09 (−0.40,0.23) |
Abbreviations: TF total fatty acids; FF free fatty acids; TG triglycerides; CE cholesterol esters; PL phospholipids.
Significant, independent effects of ethnicity on desaturase activity were identified with regression models incorporating ethnicity and potential confounding variables, according to the general structure: desaturase activity = b1.(African Caribbean ethnicity) + b2.(Asian Indian ethnicity) + b3.(BMI) + b4.(waist circumference) + b5.(triglycerides) + b6.(HDL cholesterol).
Significances * p < 0.05; † p < 0.01; § p < 0.001 refer to the significance of coefficients b1 and b2 and give the significance of the effects of African Caribbean and Asian Indian ethnicity, respectively, relative to white European ethnicity.