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. 2013 Mar 21;8(3):e59580. doi: 10.1371/journal.pone.0059580

Figure 4. Contextual fear conditioning and extinction in FMR1−/− mice and WT littermates.

Figure 4

(A) Acquisition of contextual fear conditioning. Mice were placed in a context for 3 min and received a foot shock every 60 sec for 5 times. Mice significantly increase freezing responses when compared to baseline (BL) measures before US presentation **p<0.01; ***p<0.001 vs. baseline (pairwise comparison test). (B) Extinction training. Mice underwent 3 extinction sessions with and interval of 30 min on day 2. *p<0.05; **p<0.01; ***p<0.001 (genotype effect). (C) Retention test. Freezing behavior was measured on day 3 and day 8 to evaluate long-term extinction memory *p<0.05; **p<0.01 (genotype effect). Data are expressed as mean ±s.e.m.