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. 2013 Mar 21;8(3):e59411. doi: 10.1371/journal.pone.0059411

Figure 3. The effects of the Y54 and Q55 mutations on rP2X4R function.

Figure 3

(A) The ATP-concentration dependence curves for the WT and Y54 substitution mutants. (B) The Imax values for the WT and Y54 substitution mutants in the presence (gray bars) and absence (white bars) of IVM. (C) The ATP concentration response curve for the Q55 mutants. (D) The Imax values of the Q55 mutants measured in the absence (white bars) and in the presence (gray bars) of IVM. The data are shown as the mean ± SEM values from 5–26 cells per mutant; **p<0.01 between control (−IVM) and ivermectin-treated (+IVM) receptors.