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Myc inhibition triggers lung tumor regression in p53-deficient mice. (A) H&E staining of lung tissue samples derived from TREOmomyc;CMVrtTA;LSL-KRasG12D;p53ER/ER animals 15 wk after Ad-Cre infection (top panels) and after 4 wk of treatment with Omomyc (bottom panels). (B) Survival curve of control (not doxycycline-treated) TREOmomyc;CMVrtTA;LSL-KRasG12D;p53ER/ER mice versus counterparts subjected to repeated metronomic Omomyc induction as in Figure 2C.
