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CK2 and PIAS1-dependent PML degradation. (A) PIAS1-dependent PML SUMOylation is required for the phosphorylation of the PML degron by CK2 and subsequently degradation. (B) PIAS1, together with CK2 and an unknown ubiquitin E3-ligase cooperate in order to lead to PML degradation. S, SUMOylation; Ub, ubiquitination; P, phosphorylation. Arrows indicate possible cross-talks.
