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Inhibition of P-gp increases potency of PF-309.
| Cell line | PF-309 IC50 nM | PF-309 + CP-100356 IC50 nM |
|---|---|---|
| DLD-1 | 278 | 2.9 |
| Caco-2 | 300 | 9.3 |
| HCT15 | 780 | 32 |
| LS1034 | >1 uM* | 796 |
| SW1463 | >1 uM* | 215 |
| T84 | >1 uM* | 255 |
*1 uM was the maximum concentration used. 50% growth inhibition was not achieved at this concentration.
