TABLE 4.
Mio-dependent gene expression in the wandering third instar fat body
Vw1118; UAS-Dcr2; cgGAL4 and UAS-Mioi; UAS-Dcr2; cgGAL4 larvae were reared on a 0.7 m HSD, and FBs were isolated for RNA extraction. A two-tailed Student's t test was used to derive p values. For simplicity, only a selection of genes is shown here; for full data, please see GEO accession number GSE43734. ctl, control.
| CG number/category | Name | Fold change Mioi/ctl | p vs. ctl |
|---|---|---|---|
| Glycolysis | |||
| CG8251 | Pgi | 0.38 | 0.024 |
| CG6058 | Aldolase | 0.27 | 0.012 |
| CG3127 | Pgk | 1.79 | 0.003 |
| Pyruvate metabolism | |||
| CG8808 | Pdk | 0.21 | 0.001 |
| CG7010 | PDH | 0.38 | 0.002 |
| CG5261 | PDH | 0.39 | 0.000 |
| Lipogenesis | |||
| CG3523 | Fas | 0.24 | 0.010 |
| CG3209 | GPAT | 1.60 | 0.007 |
| CG4729 | GPAT | 0.43 | 0.010 |
| CG17608 | GPAT | 2.22 | 0.006 |
| CG18362 | Mio/dChREBP | 0.09 | 0.000 |
| Lipolysis | |||
| CG1882 | Putative CGI-58 homology, ATGL activator | 1.84 | 0.032 |
| CG5295 | Brummer TAG lipase | 0.26 | 0.002 |
| CG5932 | TAG lipase | 6.38 | 0.005 |
| CG6277 | TAG lipase | 23.01 | 0.000 |
| CG6283 | TAG lipase | 18.92 | <0.0001 |
| CG6295 | TAG lipase | 28.01 | 0.000 |
| CG8093 | TAG lipase | >300 | 0.002 |
| CG8823 | Lip3 | 4.02 | 0.041 |
| CG10374 | Lsd-1 | 0.34 | 0.002 |
| CG9057 | Lsd-2 | 0.23 | 0.004 |
| β-Oxidation | |||
| CG2107 | CPT2 | 0.54 | 0.035 |
| CG4335 | Carnitine biosynthesis; γ-butyrobetaine dioxygenase activity | 0.27 | 0.026 |
| CG5321 | Carnitine biosynthesis; γ-butyrobetaine dioxygenase activity | 2.63 | 0.001 |
| CG11637 | Acyl-CoA dehydrogenase | 2.12 | 0.039 |
| CG5009 | Acyl-CoA dehydrogenase | 1.68 | 0.001 |
| CG9527 | Acyl-CoA dehydrogenase | 0.44 | 0.025 |
| CG9547 | Acyl-CoA dehydrogenase | 1.75 | 0.021 |
| CG6984 | Enoyl-CoA hydratase | 0.24 | 0.010 |
| CG8778 | Enoyl-CoA hydratase | 3.91 | 0.000 |
| CG4598 | Dodecenoyl-CoA Δ-isomerase | 1.99 | 0.003 |
| CG5844 | Dodecenoyl-CoA Δ-isomerase | 1.88 | 0.035 |
| Glycogenolysis | |||
| CG7254 | GlyP | 0.25 | 0.009 |
| Ketone and CoA metabolism | |||
| CG1140 | SCOT (acetoacyl-CoA synthase) | 0.95 | 0.933 |
| CG5725 | fbl (pantothenate kinase) | 0.54 | 0.198 |
| CG10932 | Acetoacyl-CoA thiolase | 2.67 | 0.005 |
| CG9149 | Acetoacyl-CoA thiolase | 3.32 | 0.000 |
| CG10399 | HMG-CoA lyase | 1.66 | 0.603 |
| CG4311 | HMG-CoA synthase | 8.03 | 0.000 |
| CG8322 | ATP-citrate lyase | 0.63 | 0.138 |
| Insulin signaling | |||
| CG5686 | Chico | 0.12 | 0.005 |
| CG3727 | Dock; dreadlocks | 0.18 | 0.016 |
| CG4141 | PI3K; Dp110 | 0.15 | 0.000 |
| CG1210 | PDK1 | 0.40 | 0.003 |
| CG5092 | TOR | 0.22 | 0.015 |
| CG6147 | TSC1 | 0.48 | 0.024 |
| CG10539 | S6K | 0.05 | 0.004 |
| CG8846 | Thor | 0.12 | 0.011 |
| CG4006 | Akt | 0.32 | 0.030 |
| CG14049 | Dilp6 | 0.12 | 0.004 |