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Smad1/5 and Smad4 bind to the Coch promoter region. A, ChIP assay was performed with the antibodies against Smad1 or Smad4 in R1 cells treated with or without BMP4 for 6 h. The immunoprecipitated DNA was amplified by quantitative PCR with the primers detecting specific promoter regions denoted in the upper panel. Data are shown as mean ± S.E. (n = 3). B, GGCGCC element in the Coch promoter is conserved across species. The AGGCGCC consensus BRE motif was generated by WebLogo.
