FIGURE 3.

Inhibition of influenza replication by LSTc decoy liposomes. Control or LSTc-containing decoy liposomes were added onto confluent monolayers of MDCK cells 30 min before infection with PR/8 (multiplicity of infection 0.01). After infection, cells were incubated in the presence of liposomes for 48 h. Viral growth was measured by a plaque forming unit assay and plotted as PFU/ml versus total LSTc concentration present in the solution. Control liposomes did not inhibit influenza growth (open squares); however, increasing concentrations of 7.5 mol% LSTc decoy liposomes inhibited PR/8 infectivity (filled circles). The dotted line denotes the limit of detection of the assay. Data shown are representative of two experiments, each with similar results.