TABLE 1.
Assessment of different decoy liposome formulations by hemagglutination inhibition assay
LSTc-containing decoy liposomes competitively bind to A/PR/8 (H1N1). Several different liposome formulations were assessed. Decoy liposomes containing 0, 1, 5, or 7.5 mol% LSTc were effective in inhibiting hemagglutination of both strains of influenza virus. Monovalent LSTc did not inhibit PR/8. “No inhibition” indicates that no inhibition was observed at the highest concentration tested. IC90 values are shown as molarity of sialic acid.
| Mol% LSTc on liposomes | HAI titer | IC90 |
|---|---|---|
| μm SA | ||
| 0 | No inhibition | N/A |
| 1 | No inhibition | >0.52 |
| 5 | 128 | 0.04 |
| 7.5 | 256 | 0.041 |
| Monovalent LSTc | No inhibition | >500,000 |