TABLE 2.
Assessment of 7.5 mol% LSTc decoy liposomes by hemagglutination inhibition assay of multiple strains of influenza A virus and Sendai virus
Decoy liposomes competitively bind to several strains of influenza virus. Decoy liposomes containing 7.5 mol% LSTc are effective at inhibiting hemagglutination of Philippines, X-31, Beijing, and PR/8 influenza strains. IC90 values are shown as molarity of sialic acid. Hemagglutination of Sendai virus is not inhibited by 7.5 mol% decoy liposomes at the highest concentration tested.
| Virus | HAI titer | IC90 |
|---|---|---|
| μm SA | ||
| Philippines H3N2 | 16 | 0.98 |
| X-31 H3N2 | 32 | 0.26 |
| Beijing H1N1 | 64 | 0.11 |
| PR/8 H1N1 | 256 | 0.041 |
| Sendai | No inhibition | >84 |