TABLE 3.
DHEA and raloxifene (RAL) affinities for E and E-PAP forms of SULT2A1
| Enzyme | Dissociation constant |
|||
|---|---|---|---|---|
| E |
E-PAP |
|||
| DHEA | RAL | DHEA | RAL | |
| μm | ||||
| WT | 1.7 (0.3)a | 1.3 (0.2) | 1.5 (0.2) | 23 (2.0) |
| L233G/L234G | 1.4 (0.3) | 1.1 (0.3) | 1.6 (0.2) | 1.5 (0.3) |
| D237S | 1.2 (0.4) | 1.6 (0.3) | 1.8 (0.4) | 1.2 (0.3) |
| E241S | 1.1 (0.3) | 1.5 (0.3) | 1.5 (0.2) | 1.4 (0.2) |
a S.E. is given in parentheses.