FIGURE 4.

Recombinant progranulin does not reorganize DMPC vesicles. A phospholipid clearance assay using recombinant human progranulin and purified human apoA-I is shown. ApoA-I cleared the DMPC vesicles (p < 0.001 compared with PBS), but progranulin did not (p > 0.05, compared with PBS). Data are presented as the mean ± S.D. Comparisons between groups were made by one-way analysis of variance followed by the Tukey-Kramer post-hoc test. Similar results were obtained in three independent experiments.