TABLE 1.

Summary of target sites and long range HDX effects on thrombin

Ligand	Target site	Long range influences
TMEGF45a	ABE I	ABE II (90s loop, 85–99), autolysis loop
PAR3(44–56)	ABE I	ABE II (90s loop, 85–99), autolysis loop
		ABEII (near the active site, 173–181)
		106 to 116, 202 to 207, −13 to −4
PAR1(49–62)	ABE I	ABE II (90s loop, 85–99)
		ABEII (near the active site, 173–181)
		106–116
Hirudin(54–65)	ABE I	ABE II (near the active site, 173–181)
		Autolysis loop
TMEGF56a	ABE I	Autolysis loop
Thrombin mAbb	ABE I	108–116
GpIbα(269–286)c	ABE II	106 to 116, 202 to 207, −13 to −4
		ABE I(65–84)
Fbg γ′(410–427)d	ABE II	106 to 116, 202 to 207, −13 to −4
		ABE I(65–84)

^a Thrombomodulin EGF domains (17, 19).

^b Monoclonal antibody against human thrombin (47).

^c GpIbα fragment (16).

^d Fibrinogen γ′ fragment (15).