Table 1.

Targets of therapeutic prostate cancer vacciness

Target antigen	Characteristics	Expression
PSA (prostate-specific antigen)	238 AA serine protease enzyme	prostate and semen
PSMA (prostate-specific membrane antigen)	238 AA serine protease enzyme	Prostate and neovasculature of other solid tumors; overexpressed in PCa
PAP (prostatic acid phosphatase)	386 AA secreted glycoprotein	Widely expressed in many nonprostatic cells (lung, kidney, brain, prostate)
TARP (T-cell receptor gamma chain alternate reading frame protein)	58 AA protein	Normal prostate, prostate, and breast Ca
NGEP (new gene expressed in prostate)	179 AA protein	Prostate only; overexpressed in PCa
PSCA (prostate stem cell antigen)	123 AA membrane glycoprotein	Prostate, bladder, colon, kidney, stomach; overexpressed in PCa and bladder Ca
STEAP (six-transmembrane epithelial antigen of the prostate)	339 AA protein	Prostate only; overexpressed in PCa
AKAP-4 (A kinase [PRKA] anchor protein 4)	854 AA protein	Multiple myeloma, prostate, testes; over-expressed in PCa
MUC 1 (mucin 1)	1255 AA protein	Colon, breast, ovarian, lung, pancreatic cancers and prostate, overexpressed in metastatic disease

AA = amino acid

Ca = cancer

PCa = prostate cancer