Table III.
Variables associated with procedural hypotension.
| Univariate | Multivariate* | ||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Mean ± SD | Procedural hypotension (n=57) | No procedural hypotension (n=569) | P Value | Slope | Odds Ratio | 95% CI | P Value |
| Age (years) | 54.5 ± 11.9 | 56.2 ± 10.2 | 0.23 | ||||
| Body Mass Index (kg/m2) | 27.7 ± 5.1 | 29.0 ± 5.3 | 0.08 | ||||
| Female Gender (%) | 70.2 | 52.4 | 0.01 | 0.58 | 0.56 | 0.30–1.05 | 0.07 |
|
| |||||||
| Procedure (mean ± SD) | |||||||
|
| |||||||
| Duration (minutes) | 23.4 ± 8.4 | 23.1 ± 9.4 | 0.89 | ||||
| Fentanyl dose (mcg) | 106.1 ± 33.5 | 105.5 ± 31.9 | 0.73 | ||||
| Midazolam dose (mg) | 5.7 ± 2.3 | 5.6 ± 2.0 | 0.78 | ||||
| Pre-procedure SBP (mmHg) | 123.2 ± 15.8 | 136.2 ± 16.3 | <0.001 | −0.03 | 0.97 | 0.95–0.99 | 0.004 |
| Pre-procedure DBP (mmHg) | 68.9 ± 11.0 | 80.4 ± 11.7 | <0.001 | −0.06 | 0.95 | 0.92–0.97 | <0.001 |
|
| |||||||
| Medications (%) | |||||||
|
| |||||||
| ACE inhibitor | 10.5 | 12.7 | 0.64 | ||||
| ARB | 5.3 | 4.4 | 0.76 | ||||
| BB | 8.8 | 7.4 | 0.70 | ||||
| CCB | 7.0 | 11.4 | 0.31 | ||||
| Diuretic | 5.3 | 11.6 | 0.15 | ||||
| Co-morbidities (%) | |||||||
| Asthma/COPD | 10.5 | 6.9 | 0.31 | ||||
| Congestive heart failure | 1.8 | 0.9 | 0.52 | ||||
| Coronary artery disease | 1.8 | 1.9 | 0.93 | ||||
*
Logistic regression analysis using backward elimination to derive odds ratios and 95% CI. All odds ratios are adjusted for the other variables entered into the model, including fentanyl dose, gender, midazolam dose, pre-procedure DBP, and pre-procedure SBP.
ACE – angiotensin converting enzyme; ARB –angiotensin receptor blocker; BB –beta blocker; CCB – calcium channel blocker; CI – confidence interval; COPD – chronic obstructive pulmonary disease; DBP – diastolic blood pressure; SD – standard deviation; SBP – systolic blood pressure