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. Author manuscript; available in PMC: 2014 Mar 4.
Published in final edited form as: Mol Pharm. 2013 Feb 4;10(3):958–966. doi: 10.1021/mp300410n

Table 2.

Physicochemical properties of metoprolol and labetalol

Compound Chemical Structure pKa Log P S+Log Pa
Metoprolol graphic file with name nihms442656t1.jpg 9.5140 2.242 1.96
Labetalol graphic file with name nihms442656t2.jpg 7.35 (OH), 9.42 (NH)41 3.0943 2.30
a

Calculated values using MedChem Designer™ Version 1.0.1.15, Simulations Plus, Inc.